The Choline Factor in One Carbon Metabolism

Methylation is a foundational biochemical process that influences everything from gene expression to cellular repair. At the heart of this process lies a critical nutrient—choline—whose role in one-carbon metabolism is often underappreciated. This whitepaper, authored by Dr. Jonathan Bortz and supported by leading scientific voices like Prof. Dr. Rima Obeid, explores how choline interplays with folate and betaine to support methylation, liver function, and overall metabolic health.

Whether you’re a nutrition scientist, health professional, or formulator, this deep dive into the methylation cycle reveals why choline deserves a central place in your understanding of cellular nutrition.

Download the full whitepaper to explore the science behind choline’s methylation advantage.