Methylation is one of the body’s most important cellular processes, influencing how genes express themselves to influence long-term health. It involves the transfer of a single carbon unit, known as a methyl group, to molecules like DNA, proteins, and neurotransmitters. It is important to note that the epigenetic process is influenced by signals in our environment, such as nutrition, stress, toxins, and lifestyle factors.
Efficient methylation supports cellular activity in both the brain and body, promoting DNA synthesis, neurotransmitter balance, and detoxification. In the brain, methylation is essential for healthy development and function, such as memory, learning, mood regulation, and cognition. Extending beyond the brain, methylation is fundamental to cardiovascular health and immune resilience, helping your body function at its best from early development through healthy aging.
And a key contributor to healthy methylation is folate, or vitamin B9.
Folate: The Heart of Methylation
Folate is an essential B vitamin for methylation, donating key methyl groups that influence DNA synthesis and cellular function. Folate also supports one-carbon metabolism by converting homocysteine to methionine, helping to manage homocysteine levels while also forming SAM, the body’s main methyl donor.
Yet not all forms of folate are equally effective. When administered as folic acid, the body must convert folate into its bioactive form, 5-methyltetrahydrofolate (5-MTHF), before it can be used. This final step can be inefficient for many people due to genetic differences, allowing folate to build up instead as unmetabolized folic acid (UMFA), resulting in potential inefficiencies to the critical methylation process.
Which is why we made Optifolin+®, the next generation of folate.
Lifespan Nutrition with Optifolin+®
From early prenatal development to healthy aging, Optifolin+ provides nutritional support as a next-generation form of bioactive folate (5-MTHF). By providing folate in its already active form, Optifolin+® can bypass any metabolic barriers that might hinder its efficacy.
Optifolin+® offers a unique methyl agent advantage as a choline-enriched ingredient, a nutrient that works synergistically with 5-MTHF to offer additional methylation support. Compared to other bioactive folates, Optifolin+® is designed for methylation, providing a 98% methyl capacity that optimizes these critical pathways.
Optimal methylation is fundamental to cellular health, influencing gene expression, neurotransmitter synthesis, and detoxification efficiency. By providing the body with bioactive folate in its methylated form, Optifolin+® supports these critical biochemical pathways to promote healthy aging at the cellular level. Nourishing methylation with precision helps sustain neurological and cardiovascular function, empowering wellness from the inside out, at every stage of life.
Optifolin® and Methylation: A Scientific Perspective
Learn from our trusted Voices of Science. In this video, Professor Igor Koturbash, Chair at the University of Arkansas for Medical Sciences, explores the importance of methylation and how Optifolin®, our patented folate solution, can support this critical process. Learn how bioavailable folate contributes to energy, mood, and cellular function, and why it matters for today’s wellness-focused consumers.
