Combatting Lipid-Enveloped Viruses – PRRSV, PEDV, ASFV and Maybe Even Covid-19 – Dr. Charlie Elrod, Natural Biologics and Dr. Josh Jackman, Tropical Innovations/Sungkyunkwan University
Dr. Charlie Elrod, Natural Biologics and Dr. Josh Jackman, Tropical Innovations/Sungkyunkwan University
Co-host: Dr. Ken Sanderson, Balchem
Episode 35: Combatting Lipid-Enveloped Viruses – PRRSV, PEDV, ASFV and Maybe Even Covid-19
Today’s podcast tackles a big topic in the global swine industry – African Swine Fever Virus (ASFV). This virus has recently been reported in Thailand and continues to spread throughout the globe. While North America looks for any sign of ASFV, it continues to struggle with other lipid-enveloped viruses as well.
Dr. Josh Jackman states that over 80% of livestock and human population epidemics and pandemics are caused by lipid enveloped viruses, making it of huge economic significance. (14:31)
Dr. Charlie Elrod spoke of balancing the need for that macrophage recruitment and fighting the infection versus keeping them away. By tamping the virus down, or reducing the viral load that results in fewer macrophages getting infected, and fewer virus particles surviving in the mucosal environment, then you’ve improved. (27:02)
Dr. Josh Jackman explains that you need more than one hole in a virus membrane to become inactive or broken down. The structural damage is really important to break the structural integrity of the virus particle. Another mode to prevent infection is with compounds that prevent the viral membranes from fusing with cellular membranes. (33:09)
Dr. Charlie Elrod mentions that when feeding GML to sows, it does get into the milk circulation and can have a positive effect on piglets in the form of antimicrobial, antiviral and anti-inflammatory activity. Being able to mitigate risks to the most susceptible neonatal animals would be a good thing. (47:01)
Dr. Josh Jackman adds that there is an association between higher GML levels and reduced disease severity. The potential is huge because GML targets lipid enveloped viruses broadly. Since you can’t predict which virus will cause the next outbreak, GML is something that has the potential to be a first-line counter measure to the next pandemic. (57:27)
Dr. Charlie Elrod closes by saying there is a lot of potential discoveries out there. We need to continue exploring and bring in different sources of genetic mechanisms or more specific mechanisms like a flavonoid. This is really just the first chapter. (1:14:37)
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This podcast is sponsored by Balchem Animal Nutrition and Health.